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极端微生物能够在极端环境中生存和繁衍,不少研究已经利用极端微生物合成聚羟基脂肪酸酯(polyhydroxyalkanoates,PHAs),实现了不需要灭菌、节约淡水、开放式连续的发酵过程。本文基于近几年国内外的最新研究进展,归纳了极端微生物合成PHAs的研究现状和成果,阐述极端微生物合成PHAs的影响因素,探讨极端微生物在合成PHAs领域的发展方向。指出未来可以通过探讨代谢机制、精细化处理廉价碳源、寻找各式极端菌以及开发新型强化发酵技术进而完善极端微生物合成PHAs的理论与技术,实现PHAs的低成本高效合成。
Abstract:Extremophiles can survive and thrive in extreme environments. A number of studies have been carried out to synthesise PHAs using extremophiles,realising an open and continuous fermentation process without the need for sterilisation,saving fresh water. Based on the latest research progress at home and abroad in recent years,this article summarises the current research status and results of PHAs synthesis by extremophiles,elucidates the influencing factors of PHAs synthesis by extremophiles,and explores the development direction of extremophiles in the field of PHAs synthesis. It points out that the theory and technology of PHAs synthesis by extremophiles can be improved by exploring the metabolic mechanism,finetuning the treatment of inexpensive carbon sources,searching for various extremophiles,and developing a new enhanced fermentation technology,so as to realize the low-cost and high-efficiency synthesis of PHAs.
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基本信息:
DOI:10.13364/j.issn.1672-6510.20240142
中图分类号:TQ323.4
引用信息:
[1]郑滢颍,尹芬,李冬娜等.极端微生物合成聚羟基脂肪酸酯的研究进展[J].天津科技大学学报,2025,40(04):12-22+80.DOI:10.13364/j.issn.1672-6510.20240142.
基金信息:
国家自然科学基金项目(32301527); 天津市自然科学基金重点项目(23JCZDJC00620); 青海理工大学“昆仑英才”人才引进科研项目(2023-QLGKLYCZX-020)